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Publicaciones 

Sci Rep. 2023 Oct 10;13(1):17137. doi: 10.1038/s41598-023-44203-6.
THE AUTOPHAGY PROTEIN DEF8 IS ALTERED IN ALZHEIMER'S DISEASE AND AΒ42-EXPRESSING DROSOPHILA BRAINS
Sebastián Oyarce-Pezoa, Guilherme Gischkow Rucatti, Francisco Muñoz-Carvajal, Nicole Sanhueza, Wileidy Gomez, Sandra Espinoza, Mario Leiva, Nicolás García, Daniela P Ponce, Carol D SanMartín, Diego Rojas-Rivera, Natalia Salvadores, María I Behrens, Ute Woehlbier, Melissa Calegaro-Nassif, Mario Sanhueza 

Alzheimers Dement. 2023 Jul;19(7):3210-3221. doi: 10.1002/alz.12995. Epub 2023 Feb 25.
A CALL FOR CLINICAL TRIAL GLOBALIZATION IN ALZHEIMER'S DISEASE AND RELATED DEMENTIA
Jorge J Llibre-Guerra  Anika Heavener  Sonia Maria Dozzi Brucki, Juan Pablo Díaz Marante, Maritza Pintado-Caipa, Yaohua Chen, María Isabel Behrens, Angela Hardi, Arianna Admirall-Sanchez, Rufus Akinyemi, Suvarna Alladi, Karen A Dorsman, Ana M Rodriguez-Salgado, Joel Solorzano, Ganesh M Babulal; Diversity and Disparity Professional Interest Area Increasing Sustained Diversity in Clinical Trials Working Group

Int J Mol Sci. 2023 Apr 17;24(8):7364. doi: 10.3390/ijms24087364.
CANCER HISTORY AVOIDS THE INCREASE OF SENESCENCE MARKERS IN PERIPHERAL CELLS OF AMNESTIC MILD COGNITIVE IMPAIRED PATIENTS
Carol D SanMartín, Felipe Salech, Daniela Paz Ponce, Jorge Concha-Cerda, Esteban Romero-Hernández, Gianella Liabeuf, Nicole K Rogers, Paola Murgas, Bárbara Bruna, Jamileth More, María I Behrens

Alzheimers Dement. 2023 Feb;19(2):721-735. doi: 10.1002/alz.12757. Epub 2022 Sep 13.
BIOMARKERS FOR DEMENTIA IN LATIN AMERICAN COUNTRIES: GAPS AND OPPORTUNITIES
Mario A Parra, Paulina Orellana, Tomas Leon, Cabello G Victoria, Fernando Henriquez, Rodrigo Gomez, Constanza Avalos, Andres Damian, Andrea Slachevsky, Agustin Ibañez, Henrik Zetterberg, Betty M Tijms, Jennifer S Yokoyama, Stefanie D Piña-Escudero, J Nicholas Cochran, Diana L Matallana, Daisy Acosta, Ricardo Allegri, Bianca P Arias-Suárez, Bernardo Barra, Maria Isabel Behrens, Sonia M D Brucki, Geraldo Busatto, Paulo Caramelli, Sheila Castro-Suarez, Valeria Contreras , Nilton Custodio , Sergio Dansilio , Myriam De la Cruz-Puebla, Leonardo Cruz de Souza, Monica M Diaz, Lissette Duque, Gonzalo A Farías, Sergio T Ferreira, Nahuel Magrath Guimet, Ana Kmaid, David Lira, Francisco Lopera, Beatriz Mar Meza, Eliane C Miotto, Ricardo Nitrini, Alberto Nuñez, Santiago O'Neill, John Ochoa, Maritza Pintado-Caipa, Elisa de Paula França Resende, Shannon Risacher, Luz Angela Rojas, Valentina Sabaj, Lucas Schilling  Allis F Sellek  Ana Sosa  Leonel T Takada  Antonio L Teixeira  Martha Unaucho-Pilalumbo, Claudia Duran-Aniotz

Lancet Reg Health Am. 2023 Jan:17:100387. doi: 10.1016/j.lana.2022.100387. Epub 2022 Nov 3.
CLASSIFICATION OF ALZHEIMER'S DISEASE AND FRONTOTEMPORAL DEMENTIA USING ROUTINE CLINICAL AND COGNITIVE MEASURES ACROSS MULTICENTRIC UNDERREPRESENTED SAMPLES: A CROSS SECTIONAL OBSERVATIONAL STUDY
Marcelo Adrián Maito, Hernando Santamaría-García, Sebastián Moguilner, Katherine L Possin, María E Godoy, José Alberto Avila-Funes, María I Behrens, Ignacio L Brusco, Martín A Bruno, Juan F Cardona, Nilton Custodio, Adolfo M García, Shireen Javandel, Francisco Lopera, Diana L Matallana, Bruce Miller, Maira Okada De Oliveira, Stefanie D Pina-Escudero, Andrea Slachevsky, Ana L Sosa Ortiz, Leonel T Takada, Enzo Tagliazuchi, Victor Valcour Nnifer S Yokoyama, Agustín Ibañez

Int J Environ Res Public Health. 2022 Nov 21;19(22):15374. doi: 10.3390/ijerph192215374.
THE IMPACT OF AYOGA-BASEDMINDFULNESSINTERVENTION VERSUSPSYCHO-EDUCATIONALSESSION FOR OLDERADULTS WITH MILDCOGNITIVEIMPAIRMENT: THEPROTOCOL OF ARANDOMIZEDCONTROLLED TRIAL
Farhang, M; Rojas, G; Martinez, P; Behrens, MI; Langer, AI; Diaz,M; Miranda-Castillo, C

Int J Mol Sci. 2022 Aug; 23(16): 9387. Published online 2022 Aug 20. doi: 10.3390/ijms23169387
SENESCENCE MARKERS IN PERIPHERAL BLOOD MONONUCLEAR CELLS IN AMNESTIC MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASE
Salech, F; SanMartin, CD; Concha-Cerda, J; Romero-Hernandez, E; Ponce, DP; Liabeuf, G; Rogers, NK; Murgas, P; Bruna,B; More, J; Behrens, MI

J Alzheimers Dis. 2022;87(4):1695-1711. doi: 10.3233/JAD-215660.
CANCER HISTORY ISASSOCIATED WITH SLOWER SPEED OF COGNITIVE DECLINE IN PATIENTS WITH AMNESTIC COGNITIVE IMPAIRMENT
Castillo-Passi, RI; Vergara, RC; Rogers, NK; Ponce, DP; Bennett, M; Behrens, MI

Aging Ment Health. 2022 Jul;26(7):1395-1416. doi: 10.1080/13607863.2021.1958145.
IMPACT OF SOCIAL ISOLATION AND COPING STRATEGIES IN OLDER ADULTS WITH MILD COGNITIVE IMPAIRMENT DURING THE COVID-19 PANDEMIC: A QUALITATIVE STUDY
Farhang, M; Miranda-Castillo, C; Behrens, MI; Castillo, E; Amar, SM; Rojas, G

Cells. 2022 Jun 7;11(12):1860. doi: 10.3390/cells11121860.
NEURONAL RUBICON REPRESSES EXTRACELLULAR APP/AMYLOID BETA DEPOSITION IN ALZHEIMER'S DISEASE
Espinoza, Sandra; Grunenwald, Felipe; Gomez, Wileidy; Garcia, Felipe; Abarzua-Catalan, Lorena; Oyarce-Pezoa, Sebastian; Fernanda Hernandez, Maria; Cortes, Bastian, I; Uhrig, arkus; Ponce, Daniela P.; Duran-Aniotz, Claudia; Hetz, Claudio; SanMartin, CaroL D.; Cornejo,Victor H.; Ezquer, Fernando; Parra, Valentina; Isabel Behrens, Maria; Manque, Patricio A.; Rojas-Rivera, Diego; Vidal, Rene L.;Woehlbier, Ute; Nassif, Melissa

Alzheimers & Dementia, 2021, 17:653–664, http://dx.doi.org/10.1002/alz.12227
DOMINANTLY INHERITED ALZHEIMER'S DISEASE IN LATIN AMERICA: GENETIC HETEROGENEITY AND CLINICAL PHENOTYPES
Llibre-Guerra, JJ; Li, Y; Allegri, RF; Mendez, PC; Surace, EI; Llibre-Rodriguez, JJ; Sosa, AL; Alaez-Verson, C; Longoria, EM; Tellez, A; Carrillo-Sanchez, K; Flores-Lagunes, LL; Sanchez, V; Takada, LT; Nitrini, R; Ferreira-Frota, NA; Benevides-Lima, J; Lopera, F; Ramirez, L; Jimenez-Velazquez, I; Schenk, C; Acosta, D; Behrens, MI; Doering, M; Ziegemeier, E; Morris, JC; McDade, E; Bateman, RJ.

Journal Of Alzheimers Disease, 2021, vol. 82, no. s1, pp. S163-S178, http://dx.doi.org/10.3233/JAD-201264
DEF8 AND AUTOPHAGY-ASSOCIATED GENES ARE ALTERED IN MILD COGNITIVE IMPAIRMENT, PROBABLE ALZHEIMER’S DISEASE PATIENTS, AND A TRANSGENIC MODEL OF THE DISEASE
Leyton, E; Matus, D; Espinoza, S; Benitez, JM; Cortes, BI; Gomez, W; Arevalo, NB; Murgas, P; Manque, P; Woehlbier, U; Duran-Aniotz, C; Hetz, C; Behrens, MI; San Martin, CD; Nassif, M.

Journal Of Alzheimers Disease, 2021, vol. 82, no. s1, pp. S283-S297, http://dx.doi.org/10.3233/JAD-201031.
ASSOCIATION OF VITAMIN D RECEPTOR POLYMORPHISMS WITH AMYLOID-BETA TRANSPORTERS EXPRESSION AND RISK OF MILD COGNITIVE IMPAIRMENT IN A CHILEAN COHORT
Arevalo, NB; Castillo-Godoy, DP; Espinoza-Fuenzalida, I; Rogers, NK; Farias, G; Delgado, C; Henriquez, M; Herrera, L; Behrens, MI; San Martin, CD

International Journal Of Molecular Sciences, 2021, 22(12), 6311 ,http://dx.doi.org/10.3390/ijms22126311
ANALYZING OLFACTORY NEURON PRECURSORS NON-INVASIVELY ISOLATED THROUGH NADH FLIM AS A POTENTIAL TOOL TO STUDY OXIDATIVE STRESS IN ALZHEIMER'S DISEASE
Gomez-Virgilio, L; Luarte, A; Ponce, DP; Bruna, BA; Behrens, MI

Journal of Alzheimer's Disease, 2021, vol. 81, no. 3, pp. 1231-1241, http://dx.doi.org/10.3233/JAD-201501
INTERVENTIONAL STUDY TO EVALUATE THE CLINICAL EFFECTS AND SAFETY OF THE NUTRACEUTICAL COMPOUND BRAINUP-10 (R) IN A COHORT OF PATIENTS WITH ALZHEIMER'S DISEASE: A MULTICENTER, RANDOMIZED, DOUBLE-BLIND, AND PLACEBO-CONTROLLED TRIAL
Guzman-Martinez, L; Farias, GA; Tapia, JP; Sanchez, MP; Fuentes, P; Gloger, S; Maccioni, RB 

Alzheimers Dement . 2021 Feb;17(2):295-313. doi: 10.1002/alz.12202.
DEMENTIA IN LATIN AMERICA: PAVING THE WAY TOWARD A REGIONAL ACTION PLAN
Parra, MA; Baez, S; Sedeno, L; Campo, CG; Santamaria-Garcia, H; Aprahamian, I; Bertolucci, PHF; Bustin, J; Bicalho, MAC; Cano-Gutierrez, C; Caramelli, P; Chaves, MLF; Cogram, P; Beber, BC; Court, FA; de Souza, LC; Custodio, N; Damian, A; de la Cruz, M; Rodriguez, RD; Brucki, SMD; Fajersztajn, L; Farias, GA; De Felice et al. 

Revista Chilena de Anestesia, 2021, Vol. 50 Núm. 3 pp. 455-462, http://dx.doi.org/10.25237/REVCHILANESTV50N03-05
ONE-YEAR POSTOPERATIVE MORTALITY IN A COHORT OF OLDER PATIENTS
Ebner P., Rumie A., González F., Gutiérrez R., Penna A. 

Jamda, 2021,  22 853-858, http://dx.doi.org/10.1016/j.jamda.2020.07.032
OSTEOSARCOPENIA PREDICTS FALLS, FRACTURES, AND MORTALITY IN CHILEAN COMMUNITY-DWELLING OLDER ADULTS
Salech, F; Marquez, C; Lera, L; Angel, B; Saguez, R; Albala, 

Journal Of Artificial Organs, 2021, 24, pages287–292 http://dx.doi.org/10.1007/s10047-020-01209-5
MOBILE ECMO IN COVID-19 PATIENT: CASE REPORT.
Daniela, M; Felipe, S; Van Nicolette, SJ; Tomas, R; Eli, V; Jorge, R; Christian, F; Roberto, C; Jose, I; Luisa, D; Rodrigo, D

International Journal Of Geriatric Psychiatry, 2021, 36:302-313, http://dx.doi.org/10.1002/gps.5425
CONSOLIDATED FRAMEWORK FOR ADVANCING IMPLEMENTATION SCIENCE FOR THE IMPLEMENTATION PROCESS AND ADHERENCE ASSESSMENT OF A NON-PHARMACOLOGICAL DELIRIUM PREVENTION PROGRAM
Garrido, MA; Alvarez, EA; Ponce, DP; Salech, F; Tobar, DI; Tobar, EA

Front Genet, 2021, Jul 28;12:649764, doi: 10.3389/fgene.2021.649764. eCollection 2021.
FILTERING OF DATA-DRIVEN GENE REGULATORY NETWORKS USING DROSOPHILA MELANOGASTER AS A CASE STUDY
Yesid Cuesta-Astroz , Guilherme Gischkow Rucatti , Leandro Murgas , Carol D San Martín , Mario Sanhueza , Alberto J M Martin

Revista Chilena de Anestesia, 2020, Vol. 49 Núm. 2 pp. 255-261, http://dx.doi.org/10.25237/REVCHILANESTV49N02.10
PERIOPERATIVE ACUTE KIDNEY INJURY. A STUDY PROTOCOL TODETER-MINE THE ROLE OF FIBROBLAST GROWTH FACTOR 23 AS ABIOMARKER FOR EARLY DIAGNOSIS
Nicolás Valls J., Alzola C., Toro L., Marchant F., Rumie A., Ebner P., Alzamora R., Penna A

Revista Chilena de Anestesia, 2020,  Vol. 49 Núm. 1 pp. 168-171, http://dx.doi.org/10.25237/revchilanestv49n01.15
INCREASED SENSITIVITY TO LIDOCAINE: GENETIC STUDY OF A CASE
Bravo D., Penna A., Michea L., Stutzin A.

Journal of Pain Research, 2020, Volume 2020:13 Pages 2937—2946, http://dx.doi.org/10.2147/JPR.S276710
INTRAOPERATIVE KETAMINE AND MAGNESIUM THERAPY TO CONTROL POSTOPERATIVE PAIN AFTER ABDOMINOPLASTY AND/OR LIPOSUCTION: A CLINICAL RANDOMIZED TRIAL
Varas, V; Bertinelli, P; Carrasco, P; Souper, N; Alvarez, P; Danilla, S; Egana, JI; Penna, A; Sepulveda, S; Arancibia, V; Alvarez, MG; Vergara, R

Frontiers In Aging Neuroscience, 2020, August, http://dx.doi.org/10.3389/fnagi.2020.00255
NICOTINAMIDE, A POLY [ADP-RIBOSE] POLYMERASE 1 (PARP-1) INHIBITOR, AS AN ADJUNCTIVE THERAPY FOR THE TREATMENT OF ALZHEIMER'S DISEASE
Salech, F; Ponce, DP; Paula-Lima, AC; San Martin, CD; Behrens, MI

Journal of Alzheimers Disease, 2020, 73(2):443-454, http://dx.doi.org/10.3233/JAD-190839
INVERSE RELATIONSHIP BETWEEN ALZHEIMER'S DISEASE AND CANCER: HOW IMMUNE CHECKPOINTS MIGHT EXPLAIN THE MECHANISMS UNDERLYING AGE-RELATED DISEASES
Rogers, NK; Romero, C; San Martin, CD; Ponce, DP; Salech, F; Lopez, MN; Gleisner, A; Tempio, F; Behrens, MI

Age And Ageing, 2020, Volume 49, Issue 2, March, http://dx.doi.org/10.1093/ageing/afz166
A SOFTWARE TO PREVENT DELIRIUM IN HOSPITALISED OLDER ADULTS: DEVELOPMENT AND FEASIBILITY ASSESSMENT
Alvarez, EA; Garrido, M; Ponce, DP; Pizarro, G; Cordova, AA; Vera, F; Ruiz, R; Fernandez, R; Velasquez, JD; Tobar, E; Salech, F

Rev. Méd. Chile, 2020, vol.148 no.3 Santiago , http://dx.doi.org/10.4067/S0034-98872020000300404
HYPOPHOSPHATEMIA INDUCED BY CARBOXYMALTOSE IRON AND IMATINIB. REPORT OF TWO CASES
Ivanovic-Zuvic, D; Fischman, A; Jimenez, M; Martinez, A; Ernst, D; Toro, L; Guarda, FJ; Florenzano, P.

Rev. Méd. Chile, 2020, vol.148 no.4 Santiago, http://dx.doi.org/10.4067/s0034-98872020000400558
COVID-19 EPIDEMIC IN CHILE: IMPACT ON EMERGENCY SERVICES CARE AND SPECIFIC PATHOLOGIES
Toro, L; Parra, A; Alvo, M

BMC Anesthesiology,2020, 20 Article number: 121, http://dx.doi.org/10.1186/s12871-020-01030-w
EFFECT OF SEVOFLURANE AND PROPOFOL ON TOURNIQUET-INDUCED ENDOTHELIAL DAMAGE: A PILOT RANDOMIZED CONTROLLED TRIAL FOR KNEE-LIGAMENT SURGERY
Maldonado, F; Morales, D; Gutierrez, R; Barahona, M; Cerda, O; Caceres, M

Neurología, 2019, Volumen 34, Número 6, Páginas 376-385  , http://dx.doi.org/10.1016/j.nrl.2017.01.013
VALIDATION OF THE SPANISH-LANGUAGE VERSION OF THE MONTREAL COGNITIVE ASSESSMENT TEST IN ADULTS OLDER THAN 60 YEARS
Delgado, C; Araneda, A; Behrens, MI

Frontiers In Systems Neuroscience, 2019, October http://dx.doi.org/10.3389/fnsys.2019.00056
INTRAOPERATIVE LOW ALPHA POWER IN THE ELECTROENCEPHALOGRAM IS ASSOCIATED WITH POSTOPERATIVE SUBSYNDROMAL DELIRIUM
Gutierrez, R; Egana, JI; Saez, I; Reyes, F; Briceno, C; Venegas, M; Lavado, I; Penna, A

Minerva Anestesiologica, 2019, March;85(3):326-7, http://dx.doi.org/10.23736/S0375-9393.18.13304-9
DELIRIUM IN THE POST-ANESTHESIA CARE UNIT MAY BE ASSOCIATED WITH THE DEVELOPMENT OF POSTOPERATIVE DELIRIUM IN A COHORT OF ELDERLY PATIENTS
Gutierrez, RG; Reyes, FI; Penna, A

Ebiomedicine, 2019, Volume 42, April, Pages 203-213 http://dx.doi.org/10.1016/j.ebiom.2019.03.008
GABAPENTIN INCREASES EXPRESSION OF DELTA SUBUNIT-CONTAINING GABA(A) RECEPTORS
Yu, JY; Wang, DS; Bonin, RP; Penna, A; Alavian-Ghavanini, A; Zurek, AA; Rauw, G; Baker, GB; Orser, BA

Journal Of Pain Research, 2019, Volume 2019:12 Pages 2991—2997, http://dx.doi.org/10.2147/JPR.S221131
REMIFENTANIL-INDUCED SECONDARY HYPERALGESIA IS NOT PREVENTED BY PREOPERATIVE ACETAZOLAMIDE ADMINISTRATION IN PATIENTS UNDERGOING TOTAL THYROIDECTOMY: A RANDOMIZED CONTROLLED TRIAL
Gutierrez, R; Contreras, F; Blanch, A; Bravo, D; Egana, JI; Rappoport, D; Cabane, P; Rodriguez, F; Penna, A

Rev. Méd. Chile,  2019, vol.147 no.6 Santiago, http://dx.doi.org/10.4067/S0034-98872019000600709
PREGNANCY DURING CHRONIC HEMODIALYSIS. A SERIES OF CASES
Fiedler, U; Sanhueza, ME; Toro, L

Journal Of Bone And Mineral Research, 2019, 17 May, http://dx.doi.org/10.1002/jbmr.3761
GLUCOCORTICOIDS DECREASE LONGITUDINAL BONE GROWTH IN PEDIATRIC KIDNEY TRANSPLANT RECIPIENTS BY STIMULATING THE FGF23/FGFR3 SIGNALING PATHWAY
Delucchi, A; Toro, L; Alzamora, R; Barrientos, V; Gonzalez, M; Andaur, R; Leon, P; Villanueva, F; Galindo, M; Heras, FL; Montecino, M; Moena, D; Lazcano, A; Pinto, V; Salas, P; Reyes, ML; Mericq, V; Michea, 

Journal of Bone and Mineral Research, 2019.
SAFETY OF BIOLOGICAL DMARD IN PATIENTS WITH INTERSTITIAL LUNG DISEASE FROM A CHILEAN COHORT OF PATIENTS WITH RHEUMATOID ARTHRITIS
Saavedra, S; Vergara, K; Hernandez, C; Zamorano, P; Goecke, A; Toro, L; Reyes, F

Journal Of Bone And Mineral Research, 2019, 17 May, http://dx.doi.org/10.1002/jbmr.3761
GLUCOCORTICOIDS DECREASE LONGITUDINAL BONE GROWTH IN PEDIATRIC KIDNEY TRANSPLANT RECIPIENTS BY STIMULATING THE FGF23/FGFR3 SIGNALING PATHWAY
Delucchi, A; Toro, L; Alzamora, R; Barrientos, V; Gonzalez, M; Andaur, R; Leon, P; Villanueva, F; Galindo, M; Heras, FL; Montecino, M; Moena, D; Lazcano, A; Pinto, V; Salas, P; Reyes, ML; Mericq, V; Michea, 

European Respiratory Society, 2019, vol. 54 no. suppl 63 https://doi.org/10.1183/13993003.congress-2019.PA5189
UTILITY OF MYOSITIS RELATED ANTIBODIES IN INTERSTITIAL LUNG DISEASE AND SUSPECTED AUTOIMMUNITY
Florenzano, M; Maya, J; Reyes, F; Cuellar, C; Peralta, A; Balboa, V; Toro, L; Wolff, V